0
Abstract: Slide Presentations |

MINIMAL CLINICALLY IMPORTANT DIFFERENCE (MCID) OF THE DUTCH VERSION OF THE LEICESTER COUGH QUESTIONNAIRE AND BASELINE PREDICTORS OF REACHING THE MCID AFTER SIX MONTHS FREE TO VIEW

Lenny Brokkaar, MD*; Steven M. Uil, BS; Jan Willem K. Van Den Berg, FRCP, FCCP
Author and Funding Information

Isala Klinieken, Zwolle, The Netherlands


Chest


Chest. 2007;132(4_MeetingAbstracts):468b. doi:10.1378/chest.132.4_MeetingAbstracts.468b
Text Size: A A A
Published online

Abstract

PURPOSE: The Leicester Cough Questionnaire (LCQ)is used to determine health status in patients with chronic cough. Recently, the Dutch language version of the LCQ has been validated. The next step is to determine what change in LCQ scores is significant (i.e. what is the minimal clinically important difference (MCID)). This study aimed to identify the MCID of the LCQ after 6 months in terms of patient referencing. Moreover, we were interested which baseline factors were predictive of reaching the MCID after six months.

METHODS: 335 patients visiting the outpatient cough clinic were asked to complete the LCQ on the first visit and after 6 months. A Global Rating of Change (GRC) assessment was taken to establish the MCID by patient referencing. Univariate and logistic regression analyses were preformed to assess potential predicting baseline values (sex, productive cough, smoking, hay-fever, nose complaints??, gastric complaints, use of ACE inhibitors, use of gastric acid inhibitors, use of inhaled medication, age, clinical signs of anxiety or depression).

RESULTS: 308 of the 335 patients (mean age 60±11; 101 men (30%) completed both LCQ's and the GRC. LCQ total, physical, psychological and social scores, as indicated by patient referencing in terms of the GRC (-3 or -2 or +2, or +3; n=55), were respectively 2.81, 0.84, 0.96,1.28. The use of gastric acid inhibitors was predictive of reaching the MCID in LCQ total, physical and social scores (OR's (95% confidence interval) were respectively 2.1 (1.2; 3.7); 2.4 (1.4; 4.3); 2.0 (1.1; 3.6). Depression was predictive of reaching the MCID in psychological and social domain (OR's respectively 2.2 (1.0; 4.7); 2.8 (1.2; 6.2).

CONCLUSION: Rounded, the MCID of the LCQ total is 3 points (1 point/domain). Patients with clinical signs of depression or using gastric acid inhibitors were more likely to reach the MCID than patients without clinical signs of depression or not using gastric acid inhibitors.

CLINICAL IMPLICATIONS: Patients with either signs of depression or on gastric acid inhibitors were most likely to benefit from our cough clinic.

DISCLOSURE: Lenny Brokkaar, No Financial Disclosure Information; No Product/Research Disclosure Information

Tuesday, October 23, 2007

12:30 PM - 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543