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COMPUTERIZED RESTING ECG ANALYSIS FOR THE DETECTION OF CORONARY ARTERY STENOSIS AFTER CORONARY REVASCULARIZATION IN COMPARISON WITH ANGIOGRAPHIC FINDINGS FREE TO VIEW

Michael Imhoff, MD, PhD*; Andreas Bootsveld, MD; Seyrani Yuecel, MD; Joseph T. Shen, MD; Eberhard Grube, MD PhD
Author and Funding Information

Ruhr-University Bochum, Bochum, Germany


Chest


Chest. 2007;132(4_MeetingAbstracts):466b. doi:10.1378/chest.132.4_MeetingAbstracts.466b
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Abstract

PURPOSE: To evaluate a new computerized ECG system for the detection of myocardial ischemia due to hemodynamically relevant coronary re-stenosis, de novo stenosis, or graft stenosis after revascularization.

METHODS: 213 patients (68 female, mean age 63.9 +/- 9.8) were included who were scheduled for follow-up angiography after coronary revascularization at least 6 weeks before inclusion (147 PCI, 68 CABG). Angiographic results were classified into hemodynamically relevant (stenosis) and hemodynamically non-relevant (no stenosis) coronary lesions by two angiographers independently. The 3DMP device calculated a severity score ranging from 0 to 20 where a higher score indicated a higher likelihood of myocardial ischemia due to coronary stenosis. A score of greater than 4 was defined as indicative of hemodynamically relevant coronary stenosis.

RESULTS: For patients with coronary stenosis the severity score was significantly higher than without (5.4 +/- 1.9 vs. 1.7 +/-2.1; p < 0.001, t-test). With a cut-off score of 4.0 3DMP correctly classified 192 patient (90.1% correct; sensitivity 93%, specificity 88.7%). Positive and negative predictive values were 80.5% and 96.2% respectively. The ROC area under the curve for the continuous severity score was 0.909 (95% CI: 0.867-0.952). The performance was not significantly different between patients with PCI and those with CABG (ROC AUC 0.907 [0.852-0.961] vs. 0.891 [0.803-0.978]).

CONCLUSION: 3DMP provides a resting ECG methodology which appears to be very sensitive and specific in the identification of patients with coronary stenosis after coronary revascularization. These results warrant additional studies with a direct comparison other non-invasive methods.

CLINICAL IMPLICATIONS: 3DMP may be a valuable tool for diagnosing and screening patients who have undergone coronary revascularization for re-stenosis, de novo stenosis, or graft stenosis. As a resting ECG method 3DMP may be especially advantageous when stress test methods are contraindicated.

DISCLOSURE: Michael Imhoff, No Financial Disclosure Information; No Product/Research Disclosure Information

Tuesday, October 23, 2007

12:30 PM - 2:00 PM


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