Abstract Objective: To evaluate the diagnostic accuracy of the imprint and crush smear cytology in the diagnosis of lung cancer verified in comparison with the histological diagnosis which was taken gold standard. Design: Prospective open label study.
Setting : In the department of internal medicine and pathology Institute of medical sciences. Patients: Eighty one with clinical and radiological evidences of lung lesions. interventions: All subjects fiberoptic broncoscopy performed with endobrochial growth seen. Five bits of tissue were obtained, from one bit of tissue an imprint and crush smear were prepared and rest were sent for histopathology. The imprint smear was prepared by imprinting the tissue on the clean surface of glass slide without compressing the tissue. While as crush smear was made by gently crushing the tissue between the two glass slides.
Results: Overall 49 cases (60.49%) diagnosed as malignant and 31 cases (38.2%) benign on histopathology. Forty cases out of histopathlogically proved malignat were positive for malignancy (81.6%) on crush smear cytology while as nine cases not picked up in crush smear. Imprint smears were positive for malignant in 41 case out of 49 histologically proved malignant cases (83.6%) and eight cases did not show malign ant cells on imprint smear.
conclusion :Imprint and crush cytology is an easy reliable and specific method that can be used in combination with histopathology to give earlier information about the nature of the lesion and to improve the positive and diagnostic yield of fiberoptic broncoscopy.The imprint cytology technique is quick ,reliable,sensitive and highly specific method for detect lung malignancies.
Clinical Implications: Diagnosis becomes clear at least 7 to 10 days early than histopathological diagnosis.
Rafi Jan, No Financial Disclosure Information; No Product/Research Disclosure Information