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Abstract: Poster Presentations |

SIX-MONTH POST LUNG TRANSPLANTATION SIX-MINUTE WALK DISTANCE DOES NOT PREDICT MORTALITY IN ADULT LUNG TRANSPLANTATION RECIPIENTS FREE TO VIEW

Leo Seoane, MD; Claude Pirtle, BS; Shaney Alex, MD; Maneesh Gupta, MD; David Taylor, MD; Vincent Valentine, MD; Lee M. Arcement, MD*
Author and Funding Information

Ochsner Clinic Foundation, New Orleans, LA


Chest


Chest. 2009;136(4_MeetingAbstracts):135S. doi:10.1378/chest.136.4_MeetingAbstracts.135S-a
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Abstract

PURPOSE:  Lower six minute walk (6MW) distance has been associated with increased mortality in patients with pulmonary hypertension, idiopathic pulmonary fibrosis (IPF), and COPD. However, there is a paucity of data on the prognostic ability of the 6MW in lung transplantation (LUT) recipients. We sought to determine the association between distance covered during 6MW and mortality in a diverse cohort of LUT recipients.

METHODS:  From 1991 till July 2005, 198 adult LUT were done at our center. The standard 6MW at 6 months post LUT was routinely added as an objective measure in 2000 and distance was measured in meters (m). Patients that survived less than 6 months were excluded from analysis. A historical cohort study was performed. Patients were assembled into quartiles by distance walked and differences between demographic variables were assessed with either the unpaired t test or chi square as appropriate. A regression model was constructed to assess the impact of 6MW distance walked on all-cause mortality, controlling for various confounders. Kaplan Meier survival curves were constructed by quartiles and differences between groups were tested with the Log Rank test.

RESULTS:  There were no differences between groups regarding age, gender, race, pre operative diagnosis, SLT vs. BLT, BMI, pre operative RVEF or LVEF, %HTN, %DM and CrCl. Mean distance walked for each quartile: Q1 329 +/− 33m, Q2 390 +/− 19m, Q3 457 +/− 17m, Q4 538 +/− 70m. The logistic regression model showed no impact of either demographics or distance walked on survival. The log rank (Mantel Cox) test yielded a p value 0f 0.083.

CONCLUSION:  Lower distance walked during 6MW at 6 months post LUT is not predictive of all-cause mortality in our cohort of LUT recipients, possibly due to our smaller sample size.

CLINICAL IMPLICATIONS:  Routine 6MW evaluations in post LUT recipients may not be helpful as a prognostic tool. Further studies are warranted to assess if other features of the 6MW beyond distance walked have prognostic significance.

DISCLOSURE:  Lee Arcement, No Financial Disclosure Information; No Product/Research Disclosure Information

Wednesday, November 4, 2009

12:45 PM - 2:00 PM


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