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The Correlations Between Right Heart Failure and Thrombin-antithrombin Complex and Plasminogen Activator Inhibitor-1 in Patients with Chronic Obstructive Pulmonary Disease FREE TO VIEW

Young Kim, MD*
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Yongdong Severance, Seoul, Korea


Chest. 2004;126(4_MeetingAbstracts):923S. doi:10.1378/chest.126.3.888
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PURPOSE:  Cardiac catheterization and echocardiography are used to measure right heart function. and first pass radionuclide (RI) angiography has been proven to be relatively accurate and simple and reproducible method for measuring right heart function compared with echocardiography. Now cardiac CT angiography, a new technique for measuring right heart function, is introduced and its usefulness has being investigated. In chronic obstructive pulmonary disease (COPD) patients right heart failure is developed from pulmonary hypertension and in situ thrombosis and activation of coagulation factors are well known to be cause of pulmonary hypertension. But, the correlations between coagulation factors and right heart failure is not yet studied enough. The aim of this study is to investigate the usefulness of cardiac CT angiography compared with first pass RI angiography and to evaluate the correlations between right heart failure and plasma TAT(Thrombin antithrombin complex) and PAI-1(Plasminogen activator inhibitor-1) level.

METHODS:  First pass RI angiography and cardiac CT angiography were performed on 15 patients who were diagnosed COPD to measure right heart function and plasma TAT and PAI-1 level were measured.

RESULTS:  Right heart function measured by cardiac CT angiography showed excellent correlation with right heart function measured by first pass RI angiography in COPD patients. plasma TAT level showed significant inverted correlations with the right heart function measured by first pass RI angiography.

CONCLUSION:  The present study demonstrates that cardiac CT angiography is accurate and useful method to measure right heart function compared with first pass RI angiography. and plasma TAT level is a factor related with right heart failure in COPD patients.

CLINICAL IMPLICATIONS:  In the future further study should be done about TAT in diagnosis and follow-up with right heart failure in COPD patients.

DISCLOSURE:  Y. Kim, None.




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