Abstract: Poster Presentations |

Predictors of Obstructive Airway Disease (OAD) in Post Allogenic Bone Marrow Transplant (BMT) FREE TO VIEW

Mohammad Khalid, MBBS; Sarfraz Saleemi, MD; Khaliq Agha Rehan, MD; Saleh Al Dammas, MD; Mohammed Zeitouni, MD; Ayman Kharaba, MD*
Author and Funding Information

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia


Chest. 2004;126(4_MeetingAbstracts):922S. doi:10.1378/chest.126.4_MeetingAbstracts.922S
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PURPOSE:  Establish the early predictors of development of OAD and its prevalence in post BMT patients and factors influencing its prognosis.

METHODS:  Review of 153-post (BMT) patients, pre and post BMT pulmonary function test (PFT’s) were reviewed, post BMT period ranged from 4 months to 2 years. Patients with existing OAD excluded from the study. Impact of treatment (immunosuppressive & steroid) and presence of GVHD on development of OAD recorded.

RESULTS:  3 patients excluded for pre existing OAD, 20 patients developed OAD on their first (post BMT F/U PFTs) 15 patients had − FVC, 14 − FEV, 14 − MMEF, 10 - RV, - RV/TLC 14. FVC, FEV1, MMEF & RV/TLC showed changes in all 14 patient at the same time –all 20 patient then showed a progressive worsening in their OAD. All 20 patients with declining PFT’s had GVHD which is a strong predictor of development of future OAD syndrome. 8 patients received steroids/immunosuppressive therapy but failed to show significant response.

CONCLUSION:  13% patients developed OAD. An early decline in FVC, FEV, MMFF and RV/TLC are a strong predictor of future progressive OAD. Almost all patient with OAD had GVHD. A poor response to immunosuppressive therapy was noted.

CLINICAL IMPLICATIONS:  Early recognition and new treatment measures need to be explored for post BMT OAD. GVHDImmuno-SuppressionFVCFEV1FEV1/FVCMMEF 25-75RVRV/TLC++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++

* Significant Changes : +

DISCLOSURE:  A. Kharaba, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




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