Establish the early predictors of development of OAD and its prevalence in post BMT patients and factors influencing its prognosis.
Review of 153-post (BMT) patients, pre and post BMT pulmonary function test (PFT’s) were reviewed, post BMT period ranged from 4 months to 2 years. Patients with existing OAD excluded from the study. Impact of treatment (immunosuppressive & steroid) and presence of GVHD on development of OAD recorded.
3 patients excluded for pre existing OAD, 20 patients developed OAD on their first (post BMT F/U PFTs) 15 patients had − FVC, 14 − FEV, 14 − MMEF, 10 - RV, - RV/TLC 14. FVC, FEV1, MMEF & RV/TLC showed changes in all 14 patient at the same time –all 20 patient then showed a progressive worsening in their OAD. All 20 patients with declining PFT’s had GVHD which is a strong predictor of development of future OAD syndrome. 8 patients received steroids/immunosuppressive therapy but failed to show significant response.
13% patients developed OAD. An early decline in FVC, FEV, MMFF and RV/TLC are a strong predictor of future progressive OAD. Almost all patient with OAD had GVHD. A poor response to immunosuppressive therapy was noted.
Early recognition and new treatment measures need to be explored for post BMT OAD. GVHDImmuno-SuppressionFVCFEV1FEV1/FVCMMEF 25-75RVRV/TLC++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
* Significant Changes : +
A. Kharaba, None.