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Abstract: Poster Presentations |

Prognosis of Stage I Non-Small Cell Lung Cancer Patients with Positive Pleural Lavage Cytology FREE TO VIEW

Ryoji Yamamoto, MD; Takashi Tojo, MD, FCCP*; Ryu Nakajima, MD; Kan Ideguchi, MD; Hirohito Tada, MD
Author and Funding Information

Osaka City General Hospital, Osaka, Japan


Chest


Chest. 2004;126(4_MeetingAbstracts):912S-c-913S. doi:10.1378/chest.126.4_MeetingAbstracts.912S-c
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Abstract

PURPOSE:  The purpose of this study is to clarify the prognosis of resected stage I non-small cell lung cancer patients with positive pleural lavage cytology (PLC).

METHODS:  From January 1994 to December 2001, 1025 patients underwent resections for primary lung cancer, and PLC was performed by washing with 50 ml of physical saline solution immediately after a thoracotomy in the patients with little or no pleural effusion. 490 patients were in pathological stage I, and 15 patients (3.1%) of them had positive PLC. Four patients were male and 11 female, with a mean age of 65.3 years (range 47 to 75 years). Six patients were in stage IA, and 9 in stage IB. Ten were adenocarcinoma, and 5 were squamous cell carcinoma. The pleural involvement (P factor) was 8 in p0, 4 in p1, and 3 in p2.

RESULTS:  Of 15 positive PLC patients, 4 had a recurrence of the disease, 2 in the pleural cavity, 1 in the cervical lymphnode and 1 in the lung. All four were in stage IB. 3 were adenocarcinomas, and 3 were in p2. The survival of positive PLC at 3 and 5 years were 84.4% and 57.9%. Survival was significantly poorer in patients with positive PLC results than in those with negative results (93% at 3 years, 82% at 5 years) (p<0.0001).

CONCLUSION:  Even in stage I Of 490 non-small cell lung cancer patients, 15 patients (3.1%) had positive PLC. And 4 had a recurrence of the disease, 2 in the pleural cavity, 2 in the distant lesion. All four were in stage IB. Survival was significantly poorer in patients with positive PLC results than in those with negative results.

CLINICAL IMPLICATIONS:  Even in stage I Of 490 non-small cell lung cancer patients, 15 patients (3.1%) had positive PLC. And 4 had a recurrence of the disease, and all four were in stage IB. Survival was significantly poorer in patients with positive PLC results than in those with negative results.

DISCLOSURE:  T. Tojo, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM


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