Abstract: Poster Presentations |

A Randomized Controlled Trial of Directly Observed Treatment Shortcourse (DOTS) for Childhood Tuberculosis by Using an Official DOTS Provider and Non Governmental Organizations FREE TO VIEW

Meenu Singh, MD*; Lata Kumar, MD, FIAP
Author and Funding Information

Advanced Pediatric Centre, Post Graduate Institute of Medical, Chandigarh, India


Chest. 2004;126(4_MeetingAbstracts):910S. doi:10.1378/chest.126.4_MeetingAbstracts.910S-a
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PURPOSE:  Traditionally DOTS is provided by an officially appointed accountable individual who should not be the parent of the child. Recently, non governmental organizations (NGO’s) have been recommended to be involved in provision of anti tuberculosis treatment by DOTS. This randomized controlled trial was undertaken as there are no trials comparing the two in India.

METHODS:  Children (n:128) upto 12 years of age diagnosed with tuberculosis were allotted by computerized random allocation into two groups. Group 1(n:62) was given anti tuberculosis treatment (ATT) by direct supervision provided by an officially appointed and trained DOTS provider employed under a project funded by Department of Science and Technology, UT, Chandigarh, India. Group 2 (n: 66) was given ATT by workers belonging to two locally active NGO’s. The treatment protocols used were according to the recommendations of World Health Organization (WHO) for different categories of the disease.

RESULTS:  The distribution of patients in Category I and Category III as defined by WHO was similar in the two groups (P>.05). There were no patients belonging to Category II and IV. One drop out occurred in Group 1 as the family migrated to another state. All others completed the recommended duration of treatment and showed favourable clinical and radiological response. Six months after the completion of treatment of last case randomized there are no recurrences in either group.

CONCLUSION:  DOTS provided by an NGO’s is as effective as provided by an official provider when carried out in a project setting. Acknowledgement: The project was funded by Department of Science and Technology UT, Chandigarh, India.

CLINICAL IMPLICATIONS:  Treatment of tuberculosis in children by DOTS is equally effective when given by an official Dots provider or a commited workers from NGO in India. Hence NGO’s must be involved in the Revised National Tuberculosis Programme.

DISCLOSURE:  M. Singh, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




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