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A Controlled Evaluation of the Clinical Characteristics of Central Sleep Apnea FREE TO VIEW

Imran Sharief, MBBS*; Rohit Budiharaja, MBBS; David W. Hudgel, MD
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Henry Ford Hospital, Section of Sleep Medicine, Detroit, MI


Chest. 2004;126(4_MeetingAbstracts):904S-b-905S. doi:10.1378/chest.126.4_MeetingAbstracts.904S-b
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PURPOSE:  The clinical characteristics of Central sleep apnea (CSA)are thought to be similar, but usually less severe, to those of patients with OSA but these characteristics have not been examined in a controlled fashion. Purpose of this study was to compare clinical and polysomnographic (PSG) data between CSA and OSA populations after matching for age, race and gender.

METHODS:  CSA was defined as central AH index ≥5/hr and OSA index ≤5/hr. Retrospectively we reviewed charts and PSG’s of all patients diagnosed with CSA in last 2 years (n = 38) and compared data with OSA patients selected to match (n = 38) for age (57 vs. 55), race (C 26/26, AA 12/12), and gender (M 31/31, F 7/7) from our data base.

RESULTS:  Compared to OSA patients, CSA patients presented less commonly with snoring (23/38 vs. 32/38 P = .005), and witnessed apnea (19/38 vs. 27/38 P = .04). There was no difference in Epworth Sleepiness Scale (12 ± 5 vs. 12 ± 6 P = NS). BMI was similar in both groups (38 ± 36 vs. 37 ± 36 P = NS). A history of coronary artery disease (CAD) was more prevalent in CSA patients (18/38 vs. 6/38 P = .003). Review of PSG data revealed AH index was not different between CSA and OSA (27 + 20 vs. 24 + 20 P = NS). Periodic leg movements were more prevalent in CSA as compared to OSA (27 + 89 vs. 9 + 30 P = .027).

CONCLUSION:  After controlling for age, race and gender a comparison of CSA and OSA patients revealed that CSA patients presented less commonly with a history of snoring and observed apneas, but more commonly had a history of CAD. CSA patients had a similar degree of day time sleepiness and obesity to matched OSA patients.

CLINICAL IMPLICATIONS:  Evaluation of day time sleepiness with a PSG should be considered in obese patients with a history of CAD even in those without snoring or witnessed apneas.

DISCLOSURE:  I. Sharief, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




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