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Relationship Between Non-Invasive Ventilation (NIV) Time and Clinical and Functional Results in Patients with Acute Exacerbations of COPD (AECOPD) FREE TO VIEW

Nicolino Ambrosino, MD*; Soo-Kyung Strambi, PT; Ilaria D’Amico, MD; Massimiliano Serradori, MD; Marzia Pedreschi, MD; Daniele Giannini, MD
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Cardio-Thoracic Department. Pulmonary Unit, Pisa, Italy


Chest. 2004;126(4_MeetingAbstracts):902S. doi:10.1378/chest.126.4_MeetingAbstracts.902S-a
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PURPOSE:  To evaluate clinical and functional findings in 23 patients undergoing a successful first trial of NIV in a pneumological ward for AECOPD.

METHODS:  We studied 23 patients undergoing a successful first trial of NIV in a pneumological ward for AECOPD without any other comorbidity [pH: 7.34±0.03, PaCO2 65.2±11.4 mmHg PaO2: 50.3 ±11.2 mmHg respiratory rate (RR): 26±4 bpm, dyspnea (by Borg scale BS): 5.9±1.9, Glasgow Coma Scale (GCS): 14.9±0.2, heart rate (HR): 97.1±11.7 bpm and systolic arterial blood pressure (ABP) 140.3±10.0 mmHg]. NIV was considered as successful and stopped when pH was normalized without tachypnoea or signs of respiratory muscle fatigue for more than 1 day and NIV time were the hours elapsed from starting of NIV to the last hour of actual ventilation. For each patient length of COPD (LD: 17.0±13.0 years), number of AECOPD as defined by worsening in symptoms requiring change in medical therapy in the last two years preceding NIV (2.3±1.5) were recorded.

RESULTS:  NIV time was 72.7±10.7 hours and showed a significant high correlation with number of AECOPD in the 2 years preceding NIV (R2: 0.69, p= 0.0001) No correlation was found between NIV time and blood gases, BS GCS, RR, HR, and ABP before starting of NIV nor with LD respectively.

CONCLUSION:  We conclude that high number of annual AECOPD may influence the time of NIV required to recover from ARF due to AECOPD.

CLINICAL IMPLICATIONS:  All pharmacological, and non pahrmacological tools should be used to reduce frequency of exacerbations.DISCLOSURE: N. Ambrosino, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




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