Abstract: Poster Presentations |

Efficacy of Ultrasound in the Diagnosis of Pleurodesis in Rabbits FREE TO VIEW

Edwin Donnelly, MD; Zhiwen Zhu, MD*; Kirk B. Lane, PhD; Richard W. Light, MD
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Saint Thomas Hospital, Nashville, TN


Chest. 2004;126(4_MeetingAbstracts):892S-c-893S. doi:10.1378/chest.126.4_MeetingAbstracts.892S-c
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PURPOSE:  The treatment of recurrent pleural effusion or recurrent pneumothorax frequently involves the creation of a pleurodesis. Advances in the technology have greatly improved the imaging capabilities of ultrasound (US). Ultrasound is an efficient imaging modality for the evaluation of a wide variety of chest diseases. The purposes of this study are: (1)To investigate whether US can be used for the diagnosis of pleurodesis. (2)To confirm which US image is the most important feature to diagnosis pleurodesis.

METHODS:  The utility of US in documenting pleurodesis was assessed in New Zealand white rabbits that were given a single intrapleural injection of TGF-β at doses of 1.70 μg in a volume of 2.5 ml. The side that received the injection was randomized and a sham procedure was performed on the alternate side. The ultrasonographer was blinded as to which side received the injection. All rabbits had an ultrasonic examination at three marked places on each side on days 0, 5, 9 and 14 after the intrapleural injection. At each of the three places on both sides, three US features (absence of gliding sign, pleural thickenings and pleural effusion) were evaluated and graded. The animals were sacrificed on day 14 and the macroscopic pleurodesis score was subsequently determined.

RESULTS:  All rabbits were found to have absence of the lung gliding sign in the side receiving the pleurodesis at five days and subsequently. The lung gliding sign was present on the control side at all examinations. There was a high correlation between pleurodesis score and the absence of the gliding sign in all rabbits.

CONCLUSION:  US is an efficient imaging modality for the evaluation of pleurodesis in rabbits. Absence of gliding sign is the most important feature to indicate the presence of a pleurodesis.

CLINICAL IMPLICATIONS:  US should be assessed in humans for it utility in assessing pleurodesis.

DISCLOSURE:  Z. Zhu, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




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