The thesis on allergy and atopy in sarcoidosis patients has been present as a challenge considering different immunology pathways of sarcoidosis for years. The aim of this study is to present the correlation of the low serum IgE levels in patients with chronic sarcoidosis and the serum IgE levels of the healthy control subjects, and to introduce into the discussion different possibilities of the immune response in sarcoidosis.
459 biopsy positive sarcoidosis patients and 100 healthy controls are analyzed. The patient group was divided into two subgroups: patients with acute sarcoidosis and patients with chronic sarcoidosis. Patients with positive history of allergy were excluded from the study as well as the patients with extremely high levels of the serum IgE (500 IU/ml and above). All patients and healthy controls were non-smokers, with the mean age of 46,48 years (SD 11,50) for the patients group and 48,72 years for healthy controls (SD 9,60).
The mean value of the serum IgE of all analyzed patients (459pts) was 51,57 IU/ml (SD 75,55). In the group with chronic sarcoidosis (259 pts) the mean value of the serum IgE was 43, 86 IU/ml (SD 73,78) while in the group of sarcoidosis patients with acute disease (200pts) the mean serum IgE level was 61,75 IU/ml (SD 76,96) The serum IgE mean value in the control group was 137, 56 IU/ml (SD 194,84).
Patients with chronic sarcoidosis have significantly lower values of the serum IgE compared with the patients with acute disease and healthy controls (statistic. sign p< 0,01).
The low values of the serum IgE might enlighten the new approach of the immunology in sarcoidosis patients.
V.V. Vucinic, None.