Plasma viscosity, a major determinant of blood flow in microcirculation is determined by macromolecules, eg, fibrinogen, immunglobulins, lipoproteins. Risk factors for pulmonary embolism can not be detected in majority of the patients with pulmonary embolism, and the recurrence takes places in some of them. In this study we aimed to investigate the plasma viscosity levels in patients who had previously attack of pulmonary embolism.
Nineteen patients (5 women 14 men, mean age:52 from 35 to 72) who had only one attack of pulmonary embolism and 21 healthy subjects were included in the study. Patients who had coronary artery disease, peripheral arterial disease, chronic obstructive lung disease, connective tissue disease and genetic predisposition for pulmonary embolism were not included in this study. Blood samples were drawn from all patient and the plasma viscosity were measured at 37°C. Mean time interval between completion of treatment for pulmonary embolism and blood sampling was 9±2 months.
Plasma viscosity of patients who had pulmonary embolism attack was significantly higher than that of healthy subjects (1.73±0.23 mPa.s, and 1.23+0.06 mPa.s respectively p<0.001). There were no statistically significant differences between patients and control subjects in respect to routine hematological and biochemical parameters.
We have shown that patients who had pulmonary embolism attack had increased plasma viscosity levels compared to control subjects even long after completion of the treatment.
Role of increased plasma viscosity in the pathogenesis of pulmonary embolism should be evaluated in further clinical studies.
O. Yetkin, None.