0
Abstract: Poster Presentations |

Bupropion for the treatment of nicotine dependence FREE TO VIEW

Michalis G. Patentalakis, MD; Emmanuil Kastanakis, MD; Maria Dimitriadou; Moshakis Moshos, MD; Elias G. Karabatsos, MD*; Antony E. Kopanakis, MD
Author and Funding Information

Naxos Hospital, Naxos, Greece


Chest


Chest. 2004;126(4_MeetingAbstracts):866S. doi:10.1378/chest.126.4_MeetingAbstracts.866S-a
Text Size: A A A
Published online

Abstract

PURPOSE:  The aim of the study was to estimate the smoking cessation success rates of bupropion sustained release (SR) as medical treatment given daily for 8 weeks.

METHODS:  368 individuals with mean age the 46 years (range 22 to 66 years), who smoked 10 or more cigarettes per day, had high nicotine dependence and without clinical depression, participated in this study, which took place in the special medical center of smoking cessation of a hospital in Greece. A total of 245 participants received bupropion SR 150 mg daily for 1 week and then 300 mg daily for 7 weeks (total duration of medication 8 weeks) in combination with counseling. The rest 123 were treated with advisory support. The target quitting date was one week after the beginning of treatment. Brief counseling has been provided by telephone contacts the first week of the therapy and then every 2 weeks for 3 months treatment, while the result has been recorded. Clinical visits were scheduled after 2 weeks, 2nd, 6th, and 12th month of treatment.

RESULTS:  179 (73%) individuals completed the medical treatment. The treatment has been interrupted by 27 (11.1%) individuals due to unserious side effects (Xerostomia, insomnia, anxiety, nausea) and by 39 (15.9%) due to unwillingness. 66 individuals from 179 (37%) interrupted smoking after 2 months, 59 (33%) after 3 months and 52 (29%) after 6 months treatment. Among 123 who received only advisory support, interrupted smoking 19 (15.5%) after 2 months, 16 (13%) after 3 months and 15 (12.2%) after 6 months treatment.

CONCLUSION:  Treatment with bupropion SR in combination with counseling resulted in significantly higher long-term rates of smoking cessation than use only advisory support. We observed a moderate to high percentence of side effects, which are unserious and temporary.

CLINICAL IMPLICATIONS:  Smoking cessation is associated with clear health benefits and therefore should always be a major health care goal. Behavioral and pharmacologic methods help patients stop smoking.

DISCLOSURE:  E.G. Karabatsos, None.

Wednesday, October 27, 2004

12:30 PM- 2:00 PM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543