Lung cancer is the most frequent killing malignant tumor in men and the second in women in the Czech Republic. Early stages I and II are diagnosed in less than 20%, only l2% of patient (pts) are sent to surgery and 5-year survival is only 6%. The aim of our study was to describe results of diagnosis and therapy in lung cancer pts during the period l998–2003 in the Pulmonary and Surgical Departments of University Hospital in Prague Motol.
To asses changes in diagnostic procedures and therapy results we compared two subgroups of pts. The group A was created by pts from l998–2000, the group B involved pts from 2001–2003. 1024 pts with lung cancer were prospectively followed. 415 pts created the Group A and 609 the Group B. Men to women ratio was 2:1.
Adenocarcinoma was confirmed in 24% in the Group A and in 30% in the Group B. 24% of the Group A and 31% of the Group B were diagnosed in early stages. 275 pts of the whole group of 1024 pts (27%) were sent to surgery. 55% and 60% of lobectomy were done in Group A and B, respectively. Neoadjuvant chemotherapy was applicated in 8% of pts in the Group A and in 17% of pts in the Group B. The concordance between cTNM and pTNM balanced around 55%, cTNM was underestimated in 30%, overestimated in 15% in both groups.
We conclude that the percentage of adenocarcinoma, the number of early stages diagnosed and the number of resected pts increased during the two followed period. The neoadjuvant chemotherapy was more frequently used and more parenchyma sparing resection was carried on in the period 2000–2003.
Our figures are comparable with the results of other centers in EU or US. To increase the number of resecable pts we advocate for development of new methods of lung cancer screening, for example low-dose CT, in the frame of international clinical studies.
M. Marel, None.