Abstract: Poster Presentations |

Sequential Hystological and bacteriological change on lungs from 6 to 72 hours of Mechanical Ventilation in healthy pigs FREE TO VIEW

E. A. Maldonado-Ortiz, MD*; Marcela Lopez, Nurse; Julia Ramirez, Nurse; Camerino Moreno, MD; Hector Herrera, MD
Author and Funding Information

Pulmonary and Respiratory Care Department, Hospital de la Mu, Morelia, Mexico


Chest. 2004;126(4_MeetingAbstracts):846S-b-847S. doi:10.1378/chest.126.4_MeetingAbstracts.846S-b
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PURPOSE:  Mechanical Ventilation MV and orotracheal intubation are consider the major risk factor to develop Ventilator associated Pneumonia VAP. Our objective is to compare H and bacteriological B findings on healthy lungs during 6 to 72h of MV.

METHODS:  MV protocol was conducted in HP during 6, 12, 18, 24, 48 and 72 h. In vivo/post mortem respiratory samples were obtained to H and B evaluation.

RESULTS:  All animal under MV< 24 h, showed different grade of tissue inflammation and neutrophiles aggregation, but pneumonia was absent. B growth from lung cultures was considerated colonization. HP ventilated > 24h had a different grade of HB change suggested of pneumonia from severe acute inflammatory infiltrate, localized-confluent consolidation zones, and on basal zones an abcessed areas was observed. H and B correlation of pneumonia was identified in cultures with moderate to heavy concentration of E. Coli, Streptococcus sp and Staphylococcus coag. Negative.

CONCLUSION:  The Morelia Experience data show that develop of VAP is strongly associated to the length of MV (late phase >24h vs early phase <24h) Future clinical research in animals are mandatory to define this information in order to evaluate the possible benefict in humans.

CLINICAL IMPLICATIONS:  To consider the possibility to decrease the exposure period of MV and/or use others alternatives as non invasive MV or rescue extubation when possible.

DISCLOSURE:  E.A. Maldonado-Ortiz, None.

Wednesday, October 27, 2004

12:30 PM- 2:00 PM




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