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Abstract: Poster Presentations |

Linezolid Use In Lung Transplant Recipients With Staphylococcus Aureus Broncho-Pulmonary Infection FREE TO VIEW

Maria M. Crespo, MD*
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University of Pittsburgh, Pittsburgh, PA


Chest


Chest. 2004;126(4_MeetingAbstracts):843S-b-844S. doi:10.1378/chest.126.4_MeetingAbstracts.843S-b
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Abstract

PURPOSE:  Response rates determined by clearance of S. aureus from follow-up surveillance BAL.

METHODS:  From March 2002 to October 2003, thirteen lung transplant recipients (8 bilateral, 4 single, 1 bilateral lobar) (7 cystic fibrosis, 3 interstitial lung disease, 3 emphysema) received linezolid treatment (mean 816 ± 1068 days post-transplant) for S. aureus (10 methicillin-resistant, 3 methicillin-susceptible), isolated from bronchoalveolar lavage (BAL). Response rates were determined by clearance of S. aureus from follow-up surveillance BAL.

RESULTS:  Resolution of infection occurred in 7/13 patients (54%) within 36.3 ± 29.8 days of treatment. Lung function measured by FEV1 improved from pre-treatment values of 1.69L ± 0.65 to 1.83L ± 0.64. Of the three patients having biopsy-proven pneumonia or acute bronchitis, all had complete histologic amelioration. Of the patients that had persistent S. aureus colonization, 5/6 (83%) had chronic airways disease, including bronchiectasis and/or fibrotic airway strictures. Linezolid was tolerated well and did not cause thrombocytopenia or liver function test abnormalities.

CONCLUSION:  Linezolid appears to be effective for S. aureus broncho-pulmonary infections after lung transplantation.

CLINICAL IMPLICATIONS:  Due to availability in oral formulation, linezolid may offer a significant advantage compared to intravenous antibiotic preparations. Inhalational delivery of linezolid should be explored for patients with chronic airways disease who fail systemic therapy.

DISCLOSURE:  M.M. Crespo, None.

Wednesday, October 27, 2004

12:30 PM- 2:00 PM


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