Abstract: Poster Presentations |

Increase in Airways Inflammation and Oxidative Stress Markers in Subjects with Gastroesophageal Reflux (GER) and GER Associated with Asthma FREE TO VIEW

Giovanna E. Carpagnano, MD*; Maria P. Foschino Barbaro, MD
Author and Funding Information

University of Medicine, Foggia, Bari, Italy


Chest. 2004;126(4_MeetingAbstracts):811S. doi:10.1378/chest.126.4_MeetingAbstracts.811S-c
Text Size: A A A
Published online


PURPOSE:  The aim of this work was to verify i) whether GER may worsen asthma by exacerbating the pre-existing airways inflammation and oxidative stress and ii) investigate the validity of breath condensate analysis in the study of the airways of subjects with GER.

METHODS:  We enrolled fourteen patients affected by mild asthma associated with GER (49±13 yr), nine with mild persistent asthma (39±13 yr), eight with GER (35±11 yr) and seventeen healthy subjects (33±9 yr). Sputum cells count and levels of IL-4, IL-6 and 8-isoprostane in breath condensate and supernatant were measured.

RESULTS:  A high airways neutrophilic inflammation has been observed in the airways of subjects with GER and GER and asthma, as assessed by the elevated concentrations of IL-6 observed in their breath condensate and supernatant of sputum and by cell’s sputum analysis. A concomitant increase in 8-isoprostane, as a marker of oxidative stress, has been found in the airways of these subjects. We conclude that GER is characterized by an oxidative stress that seem to worsen that already existing in asthma and by an airways neutrophilic inflammation.

CONCLUSION:  The measurement of inflammatory and oxidant markers in the breath condensate of subjects with GER mirrors that observed in the induced sputum.

CLINICAL IMPLICATIONS:  We believe that the use of breath condensate may be very useful in the study and monitoring of respiratory damage due to GER.

DISCLOSURE:  G.E. Carpagnano, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543