The gastroesophageal reflux disease has been associated with cough and asthma. Studies of asthmatic patients have proven the existence of a esophagus-bronchial vagal reflex that would provoke the augment of airways responsiveness. Goals: To investigate this vagal reflex with a bronchial provocation in patients with gastroesophageal reflux.
All the patients went through an upper digestive endoscopy. 11 patients with no evidences of GER or hiatal hernia (HH) were the control group and 10 patients with HH or GER were the test group. They all were submitted to a bronchial provocation with Carbacol.
The provocation was positive in 4 (44%) of the test group and in 3 (27%) of the control group (p= 0,64).
These data suggest that lungs of patients with GER with no respiratory symptoms might be more reactive than lungs of patients without GER, which would classify the GER disease as a risk factor for bronchial-constrictive diseases.
More studies must be made to confirm this suggestions.
E. Fiss, None.