Abstract: Poster Presentations |

Increased Fasting Plasma Insulin Levels are Associated with the Severity of Angiographic Coronary Artery Disease FREE TO VIEW

Wilbert S. Aronow, MD; Rishi Sukhija, MD*; Devraj Nayak, MD; Chul Ahn, PhD; Melvin B. Weiss, MD
Author and Funding Information

New York Medical College, Valhalla, NY


Chest. 2004;126(4_MeetingAbstracts):791S. doi:10.1378/chest.126.4_MeetingAbstracts.791S-b
Text Size: A A A
Published online


PURPOSE:  We investigated the relationship between fasting plasma insulin levels and the severity of angiographic coronary artery disease(CAD).

METHODS:  Fasting plasma insulin levels were obtained in 51 men and 31 women, mean age 60 years, with an increased body mass index who underwent coronary angiography for suspected symptomatic CAD.

RESULTS:  Of 82 patients, 37 (45%) had left main or 3-vessel CAD, 22 (27%) had 2-vessel CAD, 9 (11%) had 1-vessel CAD, and 14 (17%) had no obstructive CAD. Among the 4 groups, there was no significant difference in gender, age, dyslipidemia, and smoking. Hypertension (p=0.0003), diabetes mellitus (p=0.035), and increased fasting plasma insulin level (p<0.0001) were significantly associated with the severity of CAD. Stepwise ordinal regression analysis identified increased fasting plasma insulin level as a significant independent risk factor for the severity of CAD (p<0.0001).

CONCLUSION:  Increased fasting plasma insulin level is a significant independent risk factor for the severity of angiographic CAD.

CLINICAL IMPLICATIONS:  Patients with increasedf fasting plasma insulin levels should be treated aggressively with risk factor modification.

DISCLOSURE:  R. Sukhija, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543