Abstract: Poster Presentations |

Metabolic Syndrome and hs-CRP Association with Angiographic Coronary Artery Disease FREE TO VIEW

Kwame O. Akosah, MD*; Ana M. Schaper, PhD; Sharon I. Barnhart, BSN; Vicki L. McHugh, MS; Michelle A. Mathiason, MS
Author and Funding Information

Gundersen Lutheran Health System, La Crosse, WI


Chest. 2004;126(4_MeetingAbstracts):790S-c-791S. doi:10.1378/chest.126.4_MeetingAbstracts.790S-c
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PURPOSE:  Metabolic Syndrome (MS) and hs-CRP have been recommended for risk identification in coronary heart disease (CHD) prevention. However, it is not clear if information obtained by MS and hs-CRP is additive or redundant. We aimed to determine if MS and hs-CRP provide incremental information in coronary artery disease (CAD) risk.

METHODS:  Subjects scheduled for elective coronary angiography were prospectively evaluated for MS and hs-CRP. Exclusion criteria included older age (men > 55; women > 65), anti-lipid therapy, and prior CHD. MS was defined per NCEP III as the presence of ≥3 of the following traits: low HDL (men <40 mg/dL, women <50 mg/dL), high triglyceride (≥150 mg/dL), hypertension (≥130/85 mm Hg), fasting glucose (>/+110 mg/dL), and BMI ≥30. Elevated hs-CRP was defined as > 3mg/L. CAD was defined as stenosis ≥ 50%.

RESULTS:  CAD was present in 77 (30%) of 253 subjects. Mean age was 51±8 (55% women). MS criteria was met by 75 subjects. Mean values for hs-CRP was similar among subjects with CAD compared to those without CAD (6.4±11.1 mg/L vs. 4.2±5.5 mg/L, p=NS), but significantly higher in subjects with MS compared to those without MS (6.4±9.5 mg/L vs. 3.7±5.4 mg/L, p=0.022). The odds associated with MS and CAD was 2.6 (CI:1.5-4.6, p=0.001). Among subjects without CAD, only 23% had MS, whereas 45% of individuals with CAD met criteria for MS. When MS and hs-CRP status were considered, we found that the coexistence of MS and elevated hs-CRP was associated with increased risk (OR:3.0, CI:1.5-6.1; p=0.003).

CONCLUSION:  One-third of subjects evaluated for CAD met criteria for MS. Subjects with MS were more likely to have high-risk hs-CRP. MS is associated with coronary angiographic disease. The presence of high-risk hs-CRP in subjects with MS further increase CAD risk.

CLINICAL IMPLICATIONS:  Identifying subjects with MS as per NCEP III guidelines may help identify individuals at risk for CAD, and high-risk hs-CRP values may help identify subjects with MS at particularly high risk for CAD.

DISCLOSURE:  K.O. Akosah, None.

Wednesday, October 27, 2004

12:30 PM - 2:00 PM




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