Mixed connective tissue disease (MCTD) is a syndrome with features of systemic lupus erythematosus, systemic sclerosis, polymyositis, and rheumatoid arthritis. High titers of circulating antibodies to nuclear ribonucleoprotein are frequently identified in affected patients (pts).
Forty seven ( 34 females-13 males, aged 53±12 years) pts with MCTD were evaluated with M-mode, 2D and Doppler echocardiography. Parameters measured included: Left ventricular (LV) dimensions and the peak velocity of the tricuspid regurgitant jet for the fractional shortening (FS) and pulmonary hypertension calculation respectively. Organic valvular involvement was defined as valve thickening and/or regurgitation.
Depressed LV function (FS<29%) was present in 5 pts (10.6%) and was diffusely impaired. Valvular regurgitation was found in 6 pts (12,7%) and was mild mitral regurgitation (in two due to mitral valve prolapse). Pulmonary hypertension had 7 pts (15%), pericardial effusion 8 (17%) and LV hypertrophy 4 (8.5%) pts.
In mixed connective tissue disease cardiac abnormalities are quite common with more frequent being pulmonary hypertension and pericardial effusion.
I. Moyssakis, None.