Abstract: Slide Presentations |

Noninvasive Ventilation in the Weaning of Patients with Acute-on-Chronic Respiratory Failure due to COPD FREE TO VIEW

Gamal M. Rabie, MD*; Ashraf Z. Mohamed, MD; Rania N. Mohamed, MS
Author and Funding Information

Assiut University Hospital, Assiut, Egypt


Chest. 2004;126(4_MeetingAbstracts):755S. doi:10.1378/chest.126.4_MeetingAbstracts.755S-b
Text Size: A A A
Published online


PURPOSE:  The aim of this study was to assess the usefulness of non invasive ventilation as an early extubation and weaning technique in ACRF secondary to COPD.

METHODS:  Among 72 consecutively intubated COPD patients admitted for ACRF, a prospective, randomized controlled trial of weaning was conducted in 37 patients who failed a 2-h spontaneous breathing trial, although they met simple criteria for weaning. Conventional invasive pressure support ventilation (IPSV) was used as the control weaning technique in 18 patients (IPSV group), and NIV was applied immediately after extubation in 19 patients (NIV group).

RESULTS:  No statistical difference was found in the characteristics of the two groups at randomization. In the IPSV group, 12 of 18 patients were successfully weaned and extubated, versus 15of 19 in the NIV group (p <0.05). NIV like IPSV significantly and similarly improved gas exchange in relation to that achieved during a 2-h spontaneous breathing trial (p < 0.05). The duration of ETI was significantly shorter in the NIV (4.79± 0.87 d) than in the IPSV group (8.03 ± 1.39 d) [p < 0.001]. NIV reduced significantly the duration of ventilatory support, weaning failure, nosocomial pneumonia, ICU stay and hospital stay.

CONCLUSION:  NIV is a useful method for early weaning from invasive mechanical ventilation among COPD patients with acute on top of chronic respiratory failure.

CLINICAL IMPLICATIONS:  NIV should be considered as an early extubation and weaning technique in patients with COPD and ACRF who are difficult to wean.

DISCLOSURE:  G.M. Rabie, None.

Tuesday, October 26, 2004

12:30 PM- 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543