The side effects reported in talc-induced pleurodesis may be related to migration of talc particles or reflux of inflammatory mediators to the systemic circulation. We hypothesized that different talc size particles may induce different local and systemic inflammatory response.
Sixty rabbits were injected intrapleurally with 400 mg/kg of talc with small (< 10um) or normal (>10um). After 6, 24 or 48 hours the animals were killed and had samples of blood collected and assayed for WBC, percent neutrophil (%N), LDH, IL-8 and VEGF. Statistics: t-test.
Intrapleural injection of small talc particles produced a more intense systemic effect, with increase in %N, LDH at 48 hours and IL-8 at 24 and 48 hours, whereas normal talc produced greater VEGF levels at all times.
Small size talc particles may be responsible for a more intense systemic response in talc pleurodesis. 6 hours24 hours48 hourssmallnormalsmallnormalsmallnormalWBC (X103)9,2±3,29,9±3,38,1±3,27,3±2,86,1±2,97,8±2% N69±1573±1149±1145±1165±1230±9LDH (U/L)362±122299±91230±128223±77394±155223±81IL-8 (pg/mL)935±400573±2191832±751954±5142656±12651571±365VEGF (pg/mL)<1552±15<1555±5<1569±21%Np<0,001small vs normal at 48 hoursLDHp<0,05small vs normal at 48 hoursIL-8p<0,05small vs normal at 24 and 48 hoursVEGFP<0,05small vs normal at all times
E.H. Genofre, None.