Abstract: Poster Presentations |

Cardiac Troponin I Release in Acute Pulmonary Embolism in Relation to the Duration of Symptoms FREE TO VIEW

Gopikrishna Punukollu, MD; Ramesh M. Gowda, MD; Gaurav Lakhanpal, MD; Balendu C. Vasavada, MD; Terrence J. Sacchi, MD; Ijaz A. Khan, MD, FCCP
Author and Funding Information

Long Island College Hospital, Brooklyn, NY


Chest. 2003;124(4_MeetingAbstracts):239S. doi:10.1378/chest.124.4_MeetingAbstracts.239S-a
Text Size: A A A
Published online


PURPOSE:  To evaluate the release of cardiac troponin I in normotensive patients with acute pulmonary embolism in relation to the duration of symptoms.

METHODS:  Fifty-seven normotensive patients with acute pulmonary embolism were included in the study. Patients were divided into two groups based on the duration of symptoms, group A with symptoms < 72 hours at presentation and group B with symptoms of > 72 hours. Cardiac troponin I levels were measured twice, at presentation and 8 hours later.

RESULTS:  Among the study population, 33 patients (58%) had symptoms of > 72 hours (group A) and 24 patients (42%) had symptoms of > 72 hours (group B). There was no difference in the severity of pulmonary embolism between the two groups and both groups had similar prevalence of right ventricular dysfunction on echocardiography (55% in group A vs. 42% in group B, p=NS). Sixteen patients had elevated cardiac troponin I. All patients with elevated cardiac troponin I (n=16) were in group A. In group A, 67% (n=12) of patients with right ventricular dysfunction had elevated cardiac troponin I and 27% (n=4) of patients without right ventricular dysfunction had elevated cardiac troponin I. On subgroup analysis of patients with duration of symptoms < 72 hours at presentation, 81% of patients (n=13) with elevated cardiac troponin I had duration of symptoms < 24 hours at presentation. In patients presenting within 8 hours after symptom onset (n=7) the peak troponin I levels were found at presentation in 50% (n=4) of the patients, with the median time to peak levels being 8 hours after symptom onset.

CONCLUSION:  The dynamics of cardiac troponin I in acute pulmonary embolism in patients who present with symptoms of < 72 hours duration are different from those who present with longer symptom duration.

CLINICAL IMPLICATIONS:  The use of cardiac troponin I in risk stratification of acute pulmonary embolism may be limited to the patients presenting within 72 hours of the onset of symptoms.

Characteristics Based On The Duration Of Symptoms

CharacteristicsSymptoms < 72 hours (n=33 patients)Symptoms > 72 hours (n=24 patients)P valueAge (years)63±1764±19NSMales42%(n=14)38%(n=9)NSModerate pulmonary embolism55%(n=18)42%(n=10)NSSmall pulmonary embolism45%(n=15)58%(n=14)NSElevated cardiac troponin I48%(n=16)None<0.0001Elevated cardiac troponin I with right ventricular dysfunction67%(n=12)None0.0005Elevated cardiac troponin I without right ventricular dysfunction27%(n=4)NoneNS

DISCLOSURE:  G. Punukollu, None.

Wednesday, October 29, 2003

12:30 PM - 2:00 PM




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543