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Deep Venous Thrombosis: A Comparison of Ethnic Groups From the DVT FREE Registry FREE TO VIEW

Kenneth T. Horlander, MD; Kenneth V. Leeper, MD; Samuel Z. Goldhaber, MD; Victor F. Tapson, MD
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Emroy University School of Medicine, Atlanta, GA


Chest. 2003;124(4_MeetingAbstracts):236S. doi:10.1378/chest.124.4_MeetingAbstracts.236S-a
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PURPOSE:  Identify ethnic differences among patients with newly diagnosed DVT.

METHODS:  DVT FREE; a multicenter prospective survey of 5451 patients enrolled at 183 sites in the United States. Diagnosis of DVT confirmed by venous duplex ultrasound. There were no exclusion criteria.

RESULTS:  Demographics of patients with DVT (Table 1


Caucasian (n=3928)African American (n=930)Asian (n=23)Hispanic (n=210)Other (n=41)Unknown (n=319)Male n (%) n=2559 (47%)1866 (48)422 (45)11(48)92 (44)17 (42)151(47)Female n (%) n=2892 (53%)2062 (52)508 (55)12 (52)118 (56)24 (58)168 (53)Diagnosed as outpatients n (%)2022 (51)402 (43)9 (39)107 (51)18 (44)167 (52)Diagnosed as inpatients n (%)1906 (49)528 (57)14 (61)103 (49)23 (56)152 (48)Median Age (yrs)686161575765Median Height (cm)170.2170.2162.6165.1165.1168.9Median Body Mass Index (kg/m2)27.126.624.128.029.427.9). Of 5451 patients with DVT, 72% Caucasian (n=3928), 17% African American (n=930), 4% Hispanic (n=210), <1% Asian (n=23), 1% other (n=41), and 6% unknown (n=319). Median duration of symptoms prior to diagnosis was lowest among Asians (2 days), highest among other ethnic groups (4 days) and similar among remaining groups (3 days). Upon admission, median duration of hospitalization was longer for African-Americans and Hispanics (10 days). History of cigarette smoking (74%), hypertension (71%) and cancer (77.6%) were major comorbidities (Table 2


Comorbidity (n=5451)CaucasianAfrican AmericanAsianHispanicOtherUnknownCigarette Smoking n (%) n=2182 (40%)1611 (74)374 (17)6 (0.3)62 (2.8)12 (0.6)117 (5.3)Hypertension n (%) n=2707(50%)1914 (71)572 (21)9 (0.3)85 (3)15 (0.6)112 (4.1)Cancer n (%) n=1782 (33%)1382 (77.6)235 (13.2)9 (0.5)50 (2.8)11 (0.6)95 (5.3)). Prior to diagnosis, 25% (n=1372) of patients received prophylaxis (pharmacologic/mechanical or both): 71% Caucasians (n=969), 19% African American (n=261), 4% Hispanic (n=50), <1% Asian (n=7), 1% other (n=13), and 5% unknown (n=72). Prior treatment received by 5% (n=291) of patients: 71% Caucasians (n=206), 16% African American (n=47), 4% Hispanic (n=12), <1% Asian (n=2), <1% other (n=2), and 8% unknown (n=72). Fifty percent (n=2631) received no prior prophylaxis/treatment. Low molecular weight heparin (LMWH) used as a “bridge” to warfarin in 2143 patients (39%) and intravenous unfractionated heparin (UFH) used in 1926 patients (35%).CONCLUSIONS: There are differences between ethnic groups when DVT is diagnosed including: demographics, comorbidities, prophylaxis, and treatment. Further analysis is needed to explain these differences as well as the delayed diagnosis for some ethnic groups and the disparity between groups receiving prior DVT prophylaxis or treatment.

CLINICAL IMPLICATIONS:  This data suggests there are ethnic and treatment differences between DVT patients. These differences may impact on morbidity and mortality associated with DVT.

DISCLOSURE:  K.T. Horlander, None.

Wednesday, October 29, 2003

12:30 PM - 2:00 PM




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