It is well documented that patients with obstructive sleep apnea have a blunted respiratory drive in comparison to a normal population. We explored if the severity of sleep apnea correlated with the reduction in respiratory drive.
21 patients with documented obstructive sleep apnea by standard polysomnogram included in the study. These patients underwent respiratory drive assessment with measurement of minute ventilation (Ve) and occlusion pressure at 100ms (P0.1) using standard CO2 rebreathing technique. Correlation between the respiratory drive parameters and apnea hypopnea index was done using linear regression.
There was no correlation between the respiratory drive parameters and total apnea index or total hypopnea index. Also there was no correlation between the average duration of apnea and hypopnea and the respiratory drive. Respiratory drive did not correlate with the lowest O2 saturation
ParametersR2P valueP100 vs AHI0.0510.32P100 @ ETCO2 of 60 vs AHI0.0270.47Ve @ ETCO2 of 60 vs AHI0.1270.113
AHI = Apnea Hypopnea IndexCONCLUSIONS: The degree of respiratory drive reduction seen in OSA does not correlate with the number or the duration of apneas and hypopneas. Also there was also no correlation between the respiratory drive and the degree of hypoxia measured by O2 saturation.
H.H. El Gamal, None.