This study aims to determine the location of the nebulizer along a pediatric ventilator circuit that would deliver the greatest amount of aerosolized medication in our institution. We used an infant lung model and the Newport Breeze Ventilator with its own nebulizer drive source of 8L/min that nebulizes during inspiration only. The ventilator is set at PIP=20cm water, PEEP = 5cm water, RR = 40 , IT = 0.5 , I:E = 1:2, Flow =10L/min. The ventilator circuit used was a non-heated plastic disposable pediatric corrugated tubing attached to a size 5mm endotracheal tube (ETT). The nebulizers were placed in 3 locations as follows: at the Y-piece (proximal to the ETT) , at the water trap (mid-way along the circuit) , and adjacent to the humidifier (distal to the ETT). The nebulizers were filled with 2.5mg salbutamol solutions plus saline to make a volume fill of 4ml in each of the ten random test runs done on each location. The salbutamol content in the lung model were determined by spectrophotometry and HPLC. Results showed a mean percentage output delivered to the lung model as follows: at the Y-piece = 0.76%(SD=1.84), at the water trap = 2.86%(SD=2.45) and at the humidifier = 2.46%(SD=2.9) Analysis by One-way ANOVA showed that the difference in the nebulizer outputs are statistically significant between that at the Y-piece and the water trap or the humidifier (p=0.01). We conclude that the location of the nebulizer along a pediatric ventilator circuit that would deliver the greatest amount of aerosolized medication in our institution is at the water trap or at the humidifier. Clinical validation of these results is recommended.
J.D. Gutierrez, None.