To monitor the relationship of weight (wt) with Isoniazid (INH) and pyridoxine (B6) prophylaxis in patients(pts) with latent tuberculosis infection (LTBI).
We performed a retrospective evaluation of weight of 58 pts who received INH and B6 prophylaxis in our mid Brooklyn tuberculosis (TB) clinic between 2002 and 2003. All pts who completed 9 months of INH and B6 were included except pts with history of malignancy, congestive heart failure, steroid usage, psychiatric disorder and hypothyroidism. The record of wt at the initiation of therapy (Rx) and at the conclusion of Rx was recorded from the computerized medical records.
Out of the study population (n = 58 pts), 39 pts (67%) gained wt ranging from 1 pound (lb.) to 42 pounds (lbs.) with an average (ave) of 8.62lbs. Four pts (7%) did not loose or gain any wt. Fifteen pts (26%) lost wt ranging from 1lb. to 11lbs with an ave of 5.2 lbs. Of the 15 pts in the wt loss group (gp) 7 pts (46%), lost more than 5 lbs. and were on a voluntary wt loosing diet. In the wt gain gp 23 pts (59%) out of 39 gained more than 5lbs and 30 pts (77%) out of 39 reported increased appetite.
In our study the association between INH and B6 prophylaxis and wt shows more predilection for wt gain for which there is no reported literature. We suspect that being in a supervised program for directly observed therapy and regular contact with medical personnel caused a sense of well being which might enhance the pts appetite resulting in wt gain, though we could not compare the wt gain with a control population.
This is the first paper that examines the relation between INH and B6 prophylaxisand wt in pts with LTBI and provides a reference for future study in this area.
M.T. Alam, None.