To evaluate the profile of tuberculosis in our hospital during 1 year, studying the prevalence, general features, co-infection with HIV, diagnostic methods, associated diseases, therapeutic schemes, toxicity, clinical evolution and the prevalence of mycobacterial infection by mycobacterial other than tuberculosis (MOTT).
We evaluated 217 patients, analysing the results of microbiological, radiological, anatomophatological, laboratory results, HIV serological test, viremia level and CD4 T cells and treatment response.
Tuberculosis was found in 187 patients; MOTT in 30 (16%). Among the tuberculosis cases: 126 men, 146 caucasian, 91,4% from metropolitan region, 132 had some disease, 104 HIV positive. Pulmonary forms in 108, extrapulmonary in 47 and both in 32. Among the extrapulmonar forms, ganglionar and miliar were the most prevalent. Samples were obtained through different methods, spontaneous sputum in 103 patients, being AFB positive in 39 cases and the culture in 10, induced sputum in 43, being AFB positive in 7 and the culture in 14 cases, BAL in 41 cases, being AFB positive in 6 cases and the culture in 8. The most common radiological findings were: pleural effusion in 33, cavity in 23, consolidation in 22 and miliar in 10. In the HIV positive, the viremia nivel was from 1000 to 4600000 and CD4 count from zero to 570. Rifampin, Isoniazid, Pyrazinamide (RHZ) were used in 167 cases, Streptomicin, Isoniazid and Ethambutol (SHM) in 11 and Streptomicin, Ethionamide, Ethambutol and Pyrazinamide (SEMZ) in 1. The major reason for change the scheme was hepatotoxicity. The cure with RHZ occured in 111 patients and with SHM in 7 patients. The mortality caused by tuberculosis was 8,5%.CONCLUSIONS: The culture of samples represent an important diagnostic method. The HIV co-infection worses the evolution. Although the drugs have high efficacy the cure is still low.
This infectious disease represent a health public problem in our country, specially with co-infection with HIV.
L.A. Henn, None.