To determine the significance of mediastinal lymphadenopathy detected by CT chest in evaluation of patients with NSCLC.
A retrospective study of 116 patients with NSCLC admitted in a municipal teaching hospital over a ten-year period. The findings of CT Chest with contrast prior to surgery were correlated with the histopathology after surgery to determine the sensitivity and specificity. Lymph nodes were considered abnormal if they were > 10 mm in short-axis diameter.
The mean age of patients was 64 ± 24 years; there were 80 males and 36 females. 54 of 116 patients (46.6%) had mediastinal lymphadenopathy and 62 of 116 patients (53.4%) had no mediastinal lymphadenopathy on CT chest reading. The results are shown on the algorithm below.The sensitivity and specificity of CT chest in predicting the presence of malignant mediastinal lymph nodes were 69.2% and 80% respectively.
Significant adenopathy on CT Chest is not a reliable indicator on underlying malignancy.
As CT chest is not very sensitive and specific in detecting mediastinal lymph node involvement with malignancy, sampling of mediastinal lymph nodes remains the definitive test to detect it.
M. Alakhras, None.