Bronchodilator therapy affects ventilation-perfusion relationships in the lung. In order to asess whether such therapy may impair 02 Sat, we prospectively studied a group of 89 patients referred to our PFT laboratory for lung function studies.
Eighty-nine subjects (46 females, 43 males, age range:35-84 years; mean age:64 years) underwent pulse oximetry while performing pulmonary function studies before and during bronchodilator aerosol inhalation.
Forty-nine patients (26 females, 23 males) were diagnosed with obstructive lung disease (FEV1/FVC<70) while 40 patients either had normal lung function or restrictive defect. Nine of 49 (18%) patients with obstructive lung disease showed a mean drop of 3% in 02 Sat while receiving bronchodilator aerosol. None of the patients with normal lung function or restrictive defect showed a drop in 02 Sat (P=0.010).
Bronchodilator aerosol therapy resulted in 3 mm decrease in 02 Sat in 18% patients with obstructive lung disease.CLINICAL IMPLICATION: Patients with obstructive lung disease should receive oxygen while using bronchodilator aerosol therapy to prevent a drop in 02 Sat.
A. Al-Shrouf, None.