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Pulmonary Function, Respiratory Muscle Strength, Anthropometry and Magnetic Resonance Spectroscopy Study of Brain in COPD Asian Indians in North India FREE TO VIEW

Sanjeev Sinha, MD; R. Guleria; Virendra Kumar; Uma Sharma; N.R. Jagannathan
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AIIMS, New Delhi, India


Chest. 2003;124(4_MeetingAbstracts):168S-c-169S. doi:10.1378/chest.124.4_MeetingAbstracts.168S-c
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PURPOSE:  To investigate changes in the cerebral metabolism of nondiabetic and normolipidemic patients with COPD using localized in vivo 1H MRS, and to correlate these with the severity of disease.

METHODS:  Ten symptomatic COPD patients and 19 healthy controls participated in this study. All subjects underwent 1H MRS of brain, pulmonary function test, respiratory muscle strength, anthropometric measurements, blood sugar and lipid profile. The parieto-temporal and occipital regions were localized for 1H MRS. The metabolic ratios NAA / Cr and Cho / Cr were calculated by integrating area under the each peak.

RESULTS:  In COPD patients, the mean± SD values of FEV1 was 51.4 ± 12.3 (p= 0.0001)% predicted, FVC was 73.6±13.1(p= 0.0001), PEFR was 45.3±15.5 (p= 0.0001), FEF25-75 was 28.4±7.9 (p= 0.0001) and FEV1/FVC was 72±9.6 (p= 0.0001). The mean values of MIP and MEP in COPD patients were 4.2± 0.63 (p= 0.0001) and 4.3±0.48 (p=0.0001). These values did not have statistical correlation with the levels of cerebral metabolites.The ratio of Cho/Cr (0.81±0.28, p=0.04) was significantly high in COPD patients in occipital area. The mean value of NAA/Cr in occipital area was {1.84±0.31(p=0.38)}, which is same as in controls. There were no significant differences in the mean values of ratios of NAA/Cr and Cho/Cr in other regions of the brain. The mean values of NAA/Cr and Cho/Cr in parieto-temporal area in COPD patients were 1.82±0.45 (p= 0.81) and 0.90±0.21 (p=0.92).CONCLUSIONS: The results demonstrate that the cerebral metabolism, pulmonary functions and respiratory muscle strength altered in symptomatic COPD patients. The clinical significance of other cerebral metabolic changes in COPD patients needs to be further investigated.

CLINICAL IMPLICATIONS:  Proton magnetic resonance spectroscopy is a good predictor of cerebral metabolism in COPD patients. Further investigations required in large number of patients.

DISCLOSURE:  S. Sinha, None.

Wednesday, October 29, 2003

12:30 PM - 2:00 PM




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