Elevated serum uric acid levels were observed in clinical conditions associated with hypoxia such as heart failure, primary pulmonary hypertension and congenital heart disease with no report among COPD patients. Thus, this study was done to correlate uric acid with hypoxemia and disease severity, and to determine level of PaO2 predictive of increased uric acid among COPD patients.
Included are 110 diagnosed COPD patients according to the GOLD criteria, grouped into stable (64) or unstable (46)COPD patients. Simultaneous blood extractions for serum uric acid and ABG were determined with patient in upright position. Correlation analyses were used to determine association of different variables. Independent t-test and ANOVA were employed to determine association between uric acid with ABG, age and sex, and COPD severity respectively. To test for validity of PaO2 predictive of increased uric acid, validity measures were computed and receiver operator curves were constructed.
A high significant correlation was noted between hypoxemia and uric acid levels in both stable and unstable COPD patients (p 0.05). Likewise, a direct relationship was noted between COPD severity and uric acid levels among stable COPD patients(p <0.001), i.e., the higher the COPD severity, the higher the uric acid levels. The same relationship was not seen among unstable COPD patients (p 0.070). Utilizing the receiver operator curve, a PaO2 of ≤ 68 and 70 mmHg are predictive of increased uric acid level in both stable and unstable COPD patients.
There is a strong correlation between hypoxemia and COPD severity with serum uric acid level among stable COPD patients. A PaO2 of ≤68 and 70 mmHg were predictive of increased uric acid in both stable and unstable COPD patients respectively.CLINICAL IMPLICATION: Elevated serum uric acid level may serve as a non-invasive indicator for COPD severity and hypoxemia in stable COPD patients.
I.H. Lopez, None.