Pulmonary hemodynamics of native ASD might influence rest pulmonary function. A development of pulmonary function after non-invasive correction of ASD in identical subjects has not been yet studied.Forty four children have been studied prior to closure of ASD by Amplatz technique (at the age of 10.7± 4.7; median 9.4 years). Thirty nine of those (identical) subjects have been also studied early after correction (i.e., at the age of 11.0± 4.7; median 9.5 years). Twenty six of them have been also studied 1.1± 0.1; median 1.1 years after correction again. The same protocol including lung volume (body plethysmography), lung elasticity and airway patency measurements has been used during the whole study.In conclusion, normal lung size without any significant airway patency deviations have been found within all three measurements. Slightly higher lung elasticity with mild static hyperinflation has been persisting without changes despite corrective event. Further measurement long-term after ASD closure could confirm such a favourable PFT development.
Results (mean value of % predicted±SD)1st study *2nd study3rd studyP valueTotal lung capacity (TLC)101±18106±13103±13**Residual volume (RV) to TLC (RV/TLC)124±38116±36122±43NSLung recoil at 100% TLC (Pst100)118±23125±29120±23NSSpecific airway conductance (sGaw)73±2877±3085±42NSMaximum expiratory flow at 25% VC/TLC116±42109±34113±37NS*
the first study has been performed prior to ASD correction**
P<0.05 between 1st and 2nd study
J. Sulc, None.