Abstract: Poster Presentations |

Influence of Bicuspid Aortic Valve on Aortic Elastic Properties in Patients With Severe Aortic Insufficiency FREE TO VIEW

Jason M. Lazar, MD; Spyros Kokolis, MD; David Shenouda, DO; Luther T. Clark, MD
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University, SUNY Downstate, Brooklyn, NY


Chest. 2003;124(4_MeetingAbstracts):154S. doi:10.1378/chest.124.4_MeetingAbstracts.154S-b
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PURPOSE:  Bicuspid aortic valve (BAV) is associated with aortic root dilation, aortic dissection, and abnormal elastic properties in patients with none to mild aortic insufficiency (AI). The objective of this study was to compare elastic properties of the aorta in patients with BAVs and other causes of severe AI.MEHTODS: We prospectively studied 23 consecutive found to have severe AI on transesophageal echocardiography. The fractional area change (FAC) of the descending aorta was determined at the level of the left atrium using acoustic quantification. FAC was normalized to arterial pulse pressure (PP) and mean arterial pressure (MAP), which were determined from brachial artery sphygmomanmetry recording.

RESULTS:  39% of patients with severe AI had BAVs. Patients with BAVs were younger, 42+/−15 vs 70+/−12years,p<.001, and were less likely to have coronary artery disease 39% vs 61%,p=.04. Patients with BAVs had significantly greater FAC (11+/−4 vs 7+/−2, p=.03), FAC/PP (.20+/−.08 vs .12+/−.04, p=.015), and FAC/MAP (.15+/−.06 vs .09+/−.02, p=.049) than those without BAVs. After age adjustment, FAC, FAC/PP, and FAC/MAP remained significantly greater in the BAV group whereas CAD was no longer significant.CONCLUSIONS: BC are associated with greater aortic elasticity as compared to other causes of severe chronic AI.

CLINICAL IMPLICATIONS:  These data further suggest an intrinsic abnormality of the aorta associated with BAV.

DISCLOSURE:  J.M. Lazar, None.

Wednesday, October 29, 2003

12:30 PM - 2:00 PM




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