The evolution of cardiac lesions in patients (pts) with primary Sjogren’s Syndrome (pSS).
Sixty three (61 women – 2 men, aged 52±12 years) pts with pSS were evaluated with M-mode, 2D and Doppler echocardiography during a follow up period of 42±14 months. The left ventricular (LV) fractional shortening (FS) and the velocity of tricuspid regurgitant jet plus the right atrial pressure served as indices of LV systolic function and pulmonary systolic pressure respectively. Organic valvular involvement was defined as valve thickening and/or regurgitation. Left ventricular mass index was calculated by the Penn convention formula.
Results TableParametersFirst StudyLast StudyP-valueMitral regurgitation21 (33%)25 (39%)NSAortic regurgitation14 (22%)14 (22%)NSTricuspid regurgitation6 (9.5%)9 (14%)NSPericardial effusion3 (4.7%)5 (8%)NSPulmonary hypertension14 (22%)18 (28.5%)NSLV mass index (g.m−2)105.4 ± 14109.5 ± 26.4NSLV systolic dysfunction2 (3%)3 (4.7%)NS. All the cases with mitral and aortic regurgitation were mild at the beginning and during follow up, whereas of the 6 pts with tricuspid regurgitation 2 were moderate without deterioration at the end of the study.CONCLUSIONS: Our results show that the incidence of cardiac lesions in pts with pSS is quite frequent but they are mild and their evolution is slow.
N.J. Pantazopoulos, None.