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Can Myocardial Performance Index Detect Significant Obstructive Coronary Artery Disease FREE TO VIEW

Maddury Jyotsna, MD.
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Deemed University, Nizam’s Institute of Medical Sciences, Secunderabad, India


Chest. 2003;124(4_MeetingAbstracts):148S. doi:10.1378/chest.124.4_MeetingAbstracts.148S
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PURPOSE:  Myocardial performance index(MPI) reflects the combined systolic and diastolic left ventricular function.By Dagdelen et al MPI was used to detect critical coronary stenosis.In present prospective study this parameter was studied to know significant coronary artery disease.

METHODS:  Chronic stable angina patients without previous myocardial infarction with good left ventricular function were included in the study(63 patients). Patients in Group A were without critical coronary stenosis by coronary angiogram(32 patients). Patients in Group B were with critical coronary stenosis( >70% atleast in one vessel by coronary angiogram-31 patients). In both groups, using echocardigraphic parameters isovolumetric contraction (ICT), isovolumetric relaxation(IVRT), ejection time(ET), MPI (ICT+IRT)\ET,) were calculated. In both groups ejection fraction(EF) and fractional shortening (FS) were normal.

RESULTS:  There were no significant differences in ICT,IVRT,ET and MPI in group A and group B( 62.2 ± 23 and 65.7±47 msec,70.6±15.9 and 72.9±25.3 msec, 268.2±67.2 and 279.5±64.5 msec, 0.47±0.11 and 0.46±0.14 msec).No difference in heart rate, and systolic and diastolic blood pressures in both groups.CONCLUSIONS: Contradictory to previous reports none of the systolic or diastolic or combined echo cardiographic parameters detects critical coronary artery stenosis.

CLINICAL IMPLICATIONS:  MPI is not informative in detecting significant obstructive coronary artery disease noninvasively.

DISCLOSURE:  M. Jyotsna, None.

Wednesday, October 29, 2003

12:30 PM - 2:00 PM




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