To investigate in patients with and without peripheral arterial disease (PAD) undergoing coronary angiography for suspected coronary artery disease (CAD) the prevalence of left main CAD, 3-vessel or 4-vessel CAD, and of obstructive CAD.
Coronary angiography for suspected CAD was performed in 279 patients, mean age 71 years, with documented PAD and in 218 patients, mean age 70 years, without PAD.
Compared to patients without PAD, patients with PAD had a higher prevalence of current or ex-cigarette smoking (85% versus 62%, p<0.001), of hypertension (71% versus 61%, p<0.05), of diabetes mellitus (53% versus 17%, p<0.001), and of dylipidemia (73% versus 60%, p<0.005). Left main CAD was present in 49 of 279 patients (18%) with PAD and in 1 of 218 patients (<1%) without PAD, p<0.001. Three-vessel or 4-vessel CAD was present in 177 of 279 patients (63%) with PAD and in 25 of 218 patients (11%) without PAD, p<0.001. Obstructive CAD (>50% stenosis) was present in 273 of 279 patients (98%) with PAD versus 177 of 218 patients (81%) without PAD, p<0.001.CONCLUSIONS: In patients undergoing coronary angiography for suspected CAD, patients with PAD have a higher prevalence of left main CAD, of 3-vessel or 4-vessel CAD, and of obstructive CAD than patients without PAD.
Patients with PAD have an increased severity of CAD than patients without PAD and should be treated more aggressively with risk factor modification and with coronary revascularization.
R. Sukhija, None.