The aim of our study was to evaluate the relationship between the quality of life (QoL) and pulmonary function in asthmatic outpatients.
Thirty two ambulatory patients (19 females; mean age was 45 ± 18 years; mean asthma duration - 14 ± 18 years) have filled four QoL questionnaires: disease specific - the Mini Asthma Quality of Life Questionnaire (MiniAQLQ) and the St George’s Respiratory Questionnaire (SGRQ), and generic forms - the SF-36 and 15D. Total SF-36, 15D, SGRQ and MiniAQLQ scores, as well as the scores for individual domains of SF-36 (physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, mental health and health transition), SGRQ (symptoms, activity and impacts scores) and MiniAQLQ (limitation of activity, asthma symptoms, emotional state, environmental stimuli), were calculated for each patient. Pulmonary function was determined by means of spirometry, with following parameters: FVC(L), FVC% predicted, FEV1(L), FEV1% predicted and PEF(L).
Among all of the spirometric parameters examined, the highest degree of correlation with QoL scores was found (with Pearson′s coefficient of linear correlation) for the values of PEF(L). The highest correlation was found with the MiniAQLQ environmental stimuli domain score (r=0.496; p=0.002), the SGRQ symptoms domain score (r=-0.498; p=0.006) and total SF-36 score (r=0.411; p=0.027).CONCLUSIONS: The QoL in asthmatics, that could be well determined by the questionnaires we used in our study, strongly reflects impairment of their pulmonary function as assessed by means of spirometry.
The QoL could be successfully used in clinical research and practice as an unconventional outcome for different procedures in asthma.
B.S. Gvozdenovic, None.