Abstract: Poster Presentations |

Release of Nitric Oxide From Endothelium With Periodic Acceleration and Effect on Health Related Quality of Life FREE TO VIEW

Marvin A. Sackner, MD; Emerance Gummels, MS; Jose A. Adams, MD
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Hospital, Mount Sinai Medical Center, Miami Beach, FL


Chest. 2003;124(4_MeetingAbstracts):134S. doi:10.1378/chest.124.4_MeetingAbstracts.134S-b
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PURPOSE:  Downward descent of dicrotic notch (DN) of digital pulse in normals occurs acutely during periodic acceleration (pGz) because nitric oxide is released from eNOS due to pulsatile shear stress (Sackner et al: Am.J.Respir.Crit.Care Med.2003;167 (Suppl):A117). The latter as well as health related quality of life parameters were investigated in patients after 10 to 15 pGz treatments, i.e., 1/day, 45 min duration.

METHODS:  DN position of photoelectric plethysmographic pulse was computed by dividing (a) pulse amplitude by (b) height of dicrotic notch above end diastolic level. Heart rate (HR) was measured with ECG. pGz was applied for 45 min with 5 min baseline and recovery times using a motion platform (www.at101.com, Non-Invasive Monitoring Systems, North Bay Village, FL). a/b ratio was measured in 12 normals, mean age 45, and, 26 patients, mean age 62, viz. 8 with osteoarthritis, 4 Parkinson’s, 2 multiple sclerosis, 2 neuropathy, 1 carpal tunnel syndrome, 1 restless legs, 1 COPD, 1 asthma and fibromyalgia, 1 pulmonary fibrosis, 1 pulmonary hypertension, 2 coronary artery disease, 1 venous insufficiency, and 1 interstitial cystitis. In 15 patients, SF-36v2.0 form was filled out prior to and after 10-15 pGz treatments.

RESULTS:  a/b ratios are expressed as peak values and HR as means during period (*p<.01 & **p<.001 Mann Whitney U test between baseline and pGz). Baseline a/b and HR in normals were 2.5 and 63 and during pGz, 55** and 75*, respectively. Baseline a/b and HR in patients were 1.7 and 69 and during pGz 66** and 70, respectively. SF-36 revealed that after 10-15 pGz treatments, Vitality improved (p<.02) and there was a trend to improvement of body pain (p=.06).CONCLUSIONS: Both normals and patients respond to pGz with release of nitric oxide into circulation.

CLINICAL IMPLICATIONS:  Periodic acceleration through release of nitric oxide from endothelial nitric oxide synthase achieves beneficial effects of vasodilation and immunosuppression in chronic inflammatory diseases as reflected by significant improvement of vitality and trend to improvement of body pain..

DISCLOSURE:  M.A. Sackner, Chairman, Board of Directors, Non-Invasive Monitoring Systems, Inc., Shareholder. Discussion of product research or unlabeled uses of product.

Wednesday, October 29, 2003

12:30 PM- 2:00 PM




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