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Sarcoidosis in Greece: Clinical Data and Unusual Presentations FREE TO VIEW

Elisabeth Passalidou, MD; Fotios Drakopanagiotakis, MD; Ira Michailidou, MD; Kostantine Doukas, MD; Kleopas Petronikolos, MD; Niki Karabela, MD; Stavroula Koutsoumpou, MD; Demetrios Mermigkis, MD; Vlassis Polychronopoulos, MD
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Sismanoglio General Hospital, Athens, Greece


Chest. 2003;124(4_MeetingAbstracts):113S. doi:10.1378/chest.124.4_MeetingAbstracts.113S
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PURPOSE:  Clinical spectrum of sarcoidosis varies among different populations. The purpose of our study was to report the clinical spectrum of the disease in our center.

METHODS:  Retrospective study of 20 patients’ records admitted to our hospital for sarcoidosis during a 5-year period (1998–2002). Data included patients’ demographics, medical history, clinical presentation, radiographic findings, bronchoscopy and biopsy results.

RESULTS:  20 patients’ records were studied, 14 female and 6 male. The median age was 39.2±11 years.According to radiological staging, eight patients were evaluated as stage I, seven as stage II, and five as stage III.CD4/CD8 ratio in bronchoalveolar lavage was higher than 3.5 in all cases.In 11/20 patients the diagnosis was confirmed by transbronchial biopsy, in 2/20 by mediastinoscopy and 3/20 by skin biopsy, whilst 4/20 were diagnosed by bronchoalveolar lavage and clinicoradiological findings.Common symptoms were cough (40%), dyspnoea (35%) and weight loss (30%). Nine patients had both common and uncommon extrapulmonary manifestations. 7/9 had cutaneous lesions (erythema nodosum, sarcoidic cutaneous granulomas, coexistence with psoriasis). One patient had Loffgren’s syndrome and another had Heerford’s syndrome.Three patients had ophthalmic lesions.One female patient with a previous history of breast cancer developed a breast lump, the histopathological examination of which revealed sarcoidic granuloma.Tuberculin skin test (PPD) was positive in 3/20. One of them had concomitant sarcoidosis and active tuberculosis.In 2/20 sarcoidosis coexisted with rheumatoid arthritis.Transbronchial biopsy showed in one patient the coexistence of sarcoidosis and bronchiolitis obliterans organizing pneumonia (BOOP).CONCLUSIONS: Unusual presentations of sarcoidosis were found in 7/20 cases (BOOP, active tuberculosis, sarcoid breast granuloma, Heerford’s syndrome, concomitance with psoriasis and rheumatoid arthritis).

CLINICAL IMPLICATIONS:  Any form of sarcoidosis can be encountered in our country and clinicians should consider all these different forms in the differential diagnosis of sarcoidosis.

DISCLOSURE:  E. Passalidou, None.

Tuesday, October 28, 2003

12:30 PM - 2:00 PM




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