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Assessment of Health-Related Quality of Life in Patients With Chronic Sarcoidosis FREE TO VIEW

Violeta V. Vucinic, MD, PhD; Branislav S. Gvozdenovic; Jelica L. Videnovic-Ivanov; Snezana D. Filipovic
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Clinic, Institute of Pulmonary Diseases, Belgrade, Yugoslavia


Chest. 2003;124(4_MeetingAbstracts):110S. doi:10.1378/chest.124.4_MeetingAbstracts.110S
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INTRODUCTION:  Health-related quality of life (QoL) associated with interstitional lung diseases has hardly received an appropriate attention in clinical studies. Respiratory specific QoL questionnaires were created specifically to address the problems of the patients with COPD.

PURPOSE:  In this study we tried to evaluate the possibility of using respiratory specific St.George Respiratory Questionnaire (SGRQ) to assess health-related QoL in patients with chronic sarcoidosis.

METHODS:  Validation of the instrument was tested on the hypothesis that the worse QoL scores should correlate with more severe physiologic impairments demonstrated by pulmonary function tests and the radiological finding on the chest X ray.Respiratory specific SGRQ was administered in 103 patients (72 female) with chronic sarcoidosis. The average duration of sarcoidosis 10.6 ± 5.2 years.Total SGRQ scores as well as the scores for individual domains of SGRQ (symptoms, activity and impact scores) were calculated for each patient.A. The patients were assigned into 4 groups depending on the radiologic stage (I-IV) of sarcoidosis.B. The patients were also analyzed according to the lung function impairments (in this abstract shown by the FEV1 % predicted values.)

RESULTS:  A. There was no statistical significance between SGRQ scores and the radiological stage of the lung sarcoidosis. The result corresponding with an unpredictable course of the disease.B. The study confirmed, on the other hand, (Pearson’s coefficient of linear correlation) a statistically significant correlation between FEV1% predicted and the activity score (r=-0.22 p<0.05) and the statistically high significance between the impact scores (r=-0.319; p<0.01) and the total scores (r=-0.28; p<0.01).

CONCLUSION:  SGRQ may be sensitive instrument in an assessment of the health-related QoL in the individuals with chronic sarcoidosis.

CLINICAL IMPLICATIONS:  Although respiratory specific SGRQ was principally designed to assess health-related QoL in patients with COPD it may be used for discriminating differences in QoL in patients with chronic sarcoidosis.

DISCLOSURE:  V.V. Vucinic, None.

Tuesday, October 28, 2003

12:30 PM - 2:00 PM




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