0
Abstract: Slide Presentations |

The Sympathetic Activity and Its Correlation With Body Mass Index (BMI) in Patients With Obstructive Sleep Apnea (OSA) FREE TO VIEW

Renata Rubinsztajn, PhD; Marta Kumor, MD; Krzysztof Byskiniewicz, PhD; Ryszarda Chazan, Prof.
Author and Funding Information

Pneumology, Medical University, Warsaw, Poland


Chest


Chest. 2003;124(4_MeetingAbstracts):74S. doi:10.1378/chest.124.4_MeetingAbstracts.74S-a
Text Size: A A A
Published online

Abstract

INTRODUCTION:  The aim of the study was to estimate the sympathetic activity in patients with obstructive sleep apnea (OSAS) and to evaluate the correlation between serum concentration of epinephrine and norepinephrine compared with body mass index and other constitual parameters. All patients underwent polysomnography. They were all classified as having OSA with AHI>10.

METHODS:  30 patients (27 M,3 F),aged 30-71(x= 50,96 ±9,90)were included in the study. In 5 cases hypertensive disorder were diagnosed. Based on body mass index (BMI) the obesity was found in 15 patients and overweight in 11 ones.The serum concentration of epinephrine, norepinephrine, urine acid, glucose and lipids level were measured in all patients.The HPLC methods(BIO- Rad Laboratories)were used to estimate the concentration of catecholamines.

RESULTS:  The middle serum concentration of epinephrine in hypertension group vs non hypertension group was 97.12±45.04 vs 57.25±26.56 pg/mL ( N:10-82pg/mL, x=27pg/mL vs 10-67 pg/ml x= 25pg/mL), and norepinephrine 625,26±147,81 vs 482.57±157.27pg/mL (N:41-773pg/mL x=288pg/mL vs 95-446 pg/mL x= 286pg/mL).There were observed positive correlation between epinephrine concenration(1)and norepinephrine(2) and body weigh (kg) (r1=0.44, r2=0.44), BMI (r1=0.44. r2=0.38) and waist/hips index (r2 = 0.38). The were also statistically significant correlation between catecholamines level and with uric acid concentration(r1=0.49, r2=0.77).CONCLUSIONS: We found the higher plasma catecholamines concentration in study group than in normal population, which is suggested a chronic elevation of sympathetic activity in OSAS. There were statistically significant correlation between serum catecholamines level and body weigh, BMI, waist/hips index and serum uric acid concentration.

CLINICAL IMPLICATIONS:  Elevated sympathetic activity may explain the increased cardiovascular morbidity associated with obstructive sleep apnoea.

DISCLOSURE:  R. Chazan, Medical University of Warsaw, University monies.

Monday, October 27, 2003

8:00 AM - 9:30 AM


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543