interstitial pneumonia (UIP) is a progressive disorder characterized by
a poor response to conventional immunosuppressive agents and
significant mortality. The histologic hallmark of UIP is fibrosis,
typically patchy and subpleural and paraseptal in distribution.
Fibroblastic foci (FF) are interposed between areas of dense fibrosis
and relatively normal-appearing lung. FF are thought to represent
recent sites of injury where active collagen synthesis/fibrosis is
occurring.1 We hypothesized that patients with increased
FF at the time of open-lung biopsy would have decreased survival.