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Prognostic Value of Fibroblastic Foci in Patients With Usual Interstitial Pneumonia*

Kevin R. Flaherty, MD; Thomas V. Colby, MD, FCCP; William D. Travis, MD, FCCP; Galen B. Toews, MD, FCCP; Andrew Flint, MD; Robert L. Strawderman, III, ScM, ScD; Arvind Jain, MS; Joseph P. Lynch, III, MD, FCCP; Fernando J. Martinez, MD, FCCP
Author and Funding Information

*From the University of Michigan (Drs. Flaherty, Toews, Flint, Strawderman, Lynch, Martinez, and Mr. Jain), Ann Arbor, MI; the Mayo Clinic (Dr. Colby), Scottsdale, AZ; and the Armed Forces Institute of Pathology (Dr. Travis), Washington, DC.

Correspondence to: Fernando J. Martinez, MD, FCCP, 1500 E Medical Center Dr, 3916 Taubman Center, Ann Arbor, MI 48109-0360; e-mail: fmartine@umich.edu



Chest. 2001;120(1_suppl):S76-S77. doi:10.1378/chest.120.1_suppl.S76
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Usual interstitial pneumonia (UIP) is a progressive disorder characterized by a poor response to conventional immunosuppressive agents and significant mortality. The histologic hallmark of UIP is fibrosis, typically patchy and subpleural and paraseptal in distribution. Fibroblastic foci (FF) are interposed between areas of dense fibrosis and relatively normal-appearing lung. FF are thought to represent recent sites of injury where active collagen synthesis/fibrosis is occurring.1 We hypothesized that patients with increased FF at the time of open-lung biopsy would have decreased survival.

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