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Familial Interstitial Pulmonary Fibrosis and Linkage to Chromosome 14*

Kirk B. Lane, PhD; A. Marney; J. A. Phillips, III; E. Loyd; R. Gaddipati; J. Loyd, MD
Author and Funding Information

*From the Division of Allergy, Pulmonary, and Critical Care Medicine (Drs. Lane, Marney, Loyd, Gaddipati, and Loyd) Department of Medicine, and Division of Genetic (Dr. Phillips), Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN.

Correspondence to: Kirk B. Lane, PhD, Division of Allergy, Pulmonary, and Critical Care Medicine, T-1215 MCN, Vanderbilt University School of Medicine, 1161 21st Ave, South, Nashville, TN 37232-2650.



Chest. 2001;120(1_suppl):S75-S76. doi:10.1378/chest.120.1_suppl.S75
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Extract

Idiopathic pulmonary fibrosis (IPF) has long been recognized to have a genetic component. In 1977, Geddes et al1 reported linkage of IPF to α1-antitrypsin (AAT) alleles which are located on chromosome 14 at q32 (GB4 map SGC32639, SGC32646). In 1986, Musk et al2 reported linkage in a family with IPF to Gm (now known as IGHG3), a member of the immunoglobulin family, also located at 14q32 (GB4 map stSG12505). On the current gene map of the human genome, these two markers are relatively close. The estimated distance between these markers would be 8 Mbp.

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