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Differential Expression, Surface Binding, and Response to Connective Tissue Growth Factor in Lung Fibroblast Subpopulations*

James S. Hagood, MD; Joseph A. Lasky, MD, FCCP; James E. Nesbitt, PhD; Patricia Segarini, PhD
Author and Funding Information

*From the Department of Pediatrics, Division of Allergy and Pulmonary Medicine (Dr. Hagood), University of Alabama at Birmingham, AL; Division of Pulmonary and Critical Care Medicine (Dr. Lasky), Tulane University Medical Center, New Orleans, LA; and Fibrogen, Inc. (Drs. Nesbitt and Segarini), S. San Francisco, CA.

Correspondence to: James S. Hagood, MD, Pediatric Allergy and Pulmonary Medicine, University of Alabama at Birmingham, 620 ACC, 1600 7th Ave S., Birmingham, AL 35233; email: jhagood@peds.uab.edu



Chest. 2001;120(1_suppl):S64-S66. doi:10.1378/chest.120.1_suppl.S64
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1Lasky, JA, Ortiz, LA, Tonthat, B, et al (1998) Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis.Am J Physiol275,L365-L3712Allen, JT, Knight, RA, Bloor, CA, et al Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.Am J Respir Cell Mol Biol1999;21,693-7003Lau, LF, Lam, SC The CCN family of angiogenic regulators: the integrin connection.Exp Cell Res1999;248,44-574Oemar, BS, Luscher, TF Connective tissue growth factor: friend or foe?Arterioscler Thromb Vasc Biol1997;17,1483-14895Igarashi, A, Nashiro, K, Kikuchi, K, et al Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders.J Invest Dermatol1996;106,729-7336Frazier, K, Willams, S, Kothapalli, D, et al Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor.J Invest Dermatol1996;107,404-4117Kothapalli, D, Hayashi, N, Grotendorst, GR Inhibition of TGF-β–stimulated CTGF gene expression and anchorage- independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle.FASEB J1998;12,1151-11618Hagood, JS, Miller, PJ, Lasky, JA, et al Differential expression of platelet-derived growth factor-α receptor by Thy-1(−) and Thy-1(+) lung fibroblasts.Am J Physiol1999;277,L218-L2249Kireeva, ML, Latinkic, BV, Kolesnikova, TV, et al Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development.Exp Cell Res1997;233,63-7710Lasky, JA, Friedman, M, Warshamana, S, et al Normal lung development in transgenic mice overexpressing connective tissue growth factor [abstract].Am J Respir Crit Care Med2000;161,A48011Mori, T, Kawara, S, Shinozaki, M, et al Role and interaction of connective tissue growth factor with transforming growth factor-β in persistent fibrosis: a mouse fibrosis model.J Cell Physiol1999;181,153-159

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