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Is Vasculitis an Early Pathogenic Mechanism of Interstitial Pulmonary Fibrosis?*

Angela M. Davis, MD; Joyce E. Johnson, MD; Roberto Cruz-Gervis, MD; Annis Marney, BA; Yi Wei Tang, MD, PhD; James E. Loyd, MD; R. Stokes Peebles, MD
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*From the Department of Medicine (Drs. Davis, Cruz-Gervis, Loyd, and Peebles, and Ms. Marney), Division of Allergy/Pulmonary/Critical Care, the Division of Infectious Diseases (Dr. Tang), and Department of Pathology (Dr. Johnson), Vanderbilt University Medical Center, Nashville, TN.

Correspondence to: Angela M. Davis, MD, Research Fellow, Division of Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2605; Angela.Davis@mcmail.vanderbilt.edu



Chest. 2001;120(1_suppl):S57. doi:10.1378/chest.120.1_suppl.S57
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Extract

The characteristic high-resolution chest CT findings of idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonitis (UIP) include subpleural arcading, which is a focal wedge-shaped density below the pleural surface and intralobular linear areas of honeycombing. The pathogenic mechanism is unknown, but it suggests an anatomic origin, as in disease of a small airway or vessel. Vasculature changes in patients with IPF were first described in 1963 by Turner-Warwick as subpleural bronchopulmonary anastomoses. However, the etiology is unknown and it is not generally believed to relate to the primary pathogenesis.

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