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Epimorphin in Bleomycin-Induced Pulmonary Fibrosis in Mice*

Yasuhiro Terasaki, MD
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*From the Department of Pathology, Nippon Medical School, Tokyo, Department of 1st Internal Medicine, Kumamoto University, School of Medicine, Kumamoto, Japan.

Correspondence to: Yasuhiro Terasaki, MD, Second Department of Pathology, Kumamoto University, 2-2-1 Honjou, Kumamoto City, 860-0811, Kumamoto, Japan; e-mail:terayasu@kaiju.medic.kumamoto-u.ac.jp



Chest. 2001;120(1_suppl):S30-S32. doi:10.1378/chest.120.1_suppl.S30-a
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Epimorphin was identified as a mesenchymal cell surface-associated protein that is essential for epithelial morphogenesis. In the embryonic mouse skin and lung, epimorphin is localized strongly to the border of mesenchymal and epithelial cells by using the epimorphin antibody.1 Using primary cultured rat hepatocytes, it also has been shown that epimorphin induces the formation of hepatocyte spheroids with a bile canaliculi-like structure, which maintained albumin production even in the absence of growth factors.2 Pulmonary fibrosis is thought to be a result of the process of wound healing, and the process takes place mainly within the intra-alveolar space, which in part mimics the process of fetal lung development.3 We investigated the temporal and spatial changes in the distribution of epimorphin protein and the expression of its messenger RNA in bleomycin-induced pulmonary fibrosis in mice.

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