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Introduction: : Mechanisms of Pulmonary Fibrosis*

David Riches, PhD, Chair; G. Scott Worthen, MD, Co-Chair
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*From the Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO.

Correspondence to: David Riches, PhD, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Ave, Box C272, Denver, CO 80262



Chest. 2001;120(1_suppl):S1. doi:10.1378/chest.120.1_suppl.S1
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(CHEST 2001; 120:1S)

Although Arthur C. Clarke considered 2001 to be the first year of the new millenium, the Pope disagreed and declared the year 2000 to be the first year of the new millenium. It was therefore fitting that the first meeting of the 43rd Annual Thomas L. Petty Aspen Lung Conference in the new millenium should focus on the mechanisms of pulmonary fibrosis, an appropriate return to the theme that was last visited in this forum a decade ago. In reviewing the program from the 1990 meeting, it was striking to note the remarkable progress that has been made in understanding the processes that lead from alveolar inflammation to dysregulation of the repair process and the ensuing interstitial and alveolar fibrosis. The results of studies completed in the last decade have revealed much about the nature of the initial inflammatory response in the lung and the mechanisms of epithelial injury. We have also learned a great deal about the cytokines, chemokines, and growth factors that promote excessive collagen matrix accumulation. However, while much progress has been made, many of the underlying concepts of the pathogenesis of pulmonary fibrosis have remained unchanged. Thus, the goal of the conference this year was to develop a program that would review, question, and hopefully challenge current paradigms of the pathogenesis of these disorders.

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